rgeting different regions of the porcine apoE mRNA were tested. Since fibroblasts do notGene Attenuation in Cloned Pigsexpress the APOE gene, granulosa cells, which are known to express the APOE gene [24], were used to validate the three siRNAs. The apoE mRNA abundance in cells treated with the three different siRNAs was different than in control cells (P,0.001). This indicated that the tested siR
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